Modern molecular genetic approaches to psychiatric disease

British Medical Bulletin
N Craddock, M J Owen

Abstract

Major advances in molecular genetics over the last 15 years have made it possible to identify the genes responsible for human diseases using purely genetic approaches that do not require knowledge about disease pathophysiology. Many successes have been achieved for single gene disorders and methods are being adapted and refined for complex diseases. The main strategies include linkage and association studies to map the position of disease genes followed by investigation of potential candidate genes within these genomic regions. Successes have already been achieved in complex disorders such as diabetes and Alzheimer's disease, and it is almost certain that genes predisposing to the major psychiatric disorders will be identified over the next few years. This will lead to major advances in treatment, prevention and classification of mental illness and is likely to have a dramatic impact on clinical practice.

Citations

Dec 21, 2000·Current Psychiatry Reports·G S MalhiP McGuffin
Mar 27, 2002·Current Psychiatry Reports·Ian JonesNick Craddock
May 3, 2007·Psychological Medicine·Samuel D R StoddartLisa A Jones
Dec 21, 1996·BMJ : British Medical Journal·N CraddockM J Owen
Feb 17, 2005·Comprehensive Psychiatry·Laura Weiss RobertsKatherine A Green Hammond
Feb 8, 2006·Biological Psychiatry·Heather C WhalleyStephen M Lawrie
Mar 4, 2006·Clinical Psychology Review·Irwin D Waldman, Ian R Gizer
Jan 29, 2002·Medical Hypotheses·J Peedicayil
Feb 15, 2001·American Journal of Human Genetics·M Baron
Mar 27, 2018·Annual Review of Clinical Psychology·Ryan BogdanArpana Agrawal
May 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emrah Caylak
Aug 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·P J Asherson, S Curran
Jun 19, 2001·Annals of Medicine·I Jones, N Craddock
Feb 15, 2002·Bipolar Disorders·N CraddockJ Greening
Sep 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·N Craddock
Sep 17, 2003·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ivanor V Meira-Lima, Homero Vallada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.