Abstract
Oesophageal cancer has a reputation for poor survival, and a relatively high risk of major postoperative morbidity and mortality. Encouragingly, a recent international cancer registry study reports a doubling of survival outcomes in Ireland over the last 20 years. This study focused on both oncologic and operative outcomes in patients treated with curative intent requiring surgery at a high-volume center. All patients undergoing surgery or multimodal therapy with curative intent from 2009 to 2018 were studied. All data was recorded prospectively and maintained internally. The period 2009-2013 was compared with 2014-2018 to monitor any change in trends. Four hundred and seventy-five patients (adenocarcinoma 77%, mean age 65; 76% male; 64% neoadjuvant therapy) underwent open surgical resection, 54% via en bloc 2-stage, 19.8% en bloc 3-stage, and 26.5% by a transhiatal approach. New onset atrial fibrillation was the commonest index complication, in 108 (22.7%), 80 (18%) developed suspected pneumonia/respiratory tract infection, 20 (4.2%) an anastomotic leak, and 25 (5.2%) a chyle leak. The 90-day mortality rate was 1.2% and 0.8% at 30 days. The median survival was 77.17 months, with a 5-year survival of 56%. Consistent with regist...Continue Reading
References
Aug 1, 1990·The British Journal of Surgery·J M MüllerH Pichlmaier
Jun 1, 1980·The British Journal of Surgery·R Earlam, J R Cunha-Melo
Aug 15, 1996·The New England Journal of Medicine·T N WalshT P Hennessy
Jul 27, 2004·Annals of Surgery·Daniel DindoPierre-Alain Clavien
Aug 3, 2004·The British Journal of Surgery·G G JamiesonP G Devitt
Jul 11, 2006·The New England Journal of Medicine·David Cunningham MAGIC Trial Participants
Sep 4, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Donald E LowRichard A Kozarek
Sep 18, 2010·Irish Journal of Medical Science·K H ChangD Lowe
Jan 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·John V ReynoldsDonal Hollywood
May 4, 2012·Lancet·Surya S A Y BiereMiguel A Cuesta
Jun 1, 2012·The New England Journal of Medicine·P van HagenUNKNOWN CROSS Group
Sep 21, 2013·Annals of Surgery·Claire L DonohoeJohn V Reynolds
Nov 8, 2014·Annals of Surgery·Orla Mc CormackJohn V Reynolds
Jan 11, 2016·Journal of Gastroenterology and Hepatology·Basile NjeiJohn W Birk
Jul 28, 2016·American Journal of Respiratory and Critical Care Medicine·Sushant Govindan, Robert C Hyzy
Apr 28, 2017·Annals of Cardiothoracic Surgery·Thomas W RiceEugene H Blackstone
Jun 3, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J A GannonJ Hussey
Jun 7, 2017·The American Journal of Gastroenterology·Melina ArnoldFreddie Bray
Jun 27, 2017·Lancet·Jesper LagergrenPernilla Lagergren
Sep 1, 2017·Annals of Surgery·Frans van WorkumCamiel Rosman
Dec 6, 2017·Annals of Surgery·Donald E LowB P L Wijnhoven
Mar 24, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M van PuttenR H A Verhoeven
Sep 13, 2018·CA: a Cancer Journal for Clinicians·Freddie BrayAhmedin Jemal
Oct 3, 2018·World Journal of Surgery·Donald E LowOlle Ljungqvist
Oct 12, 2018·Annals of Surgery·Pieter C van der SluisRichard van Hillegersberg
Oct 17, 2018·Nature Reviews. Gastroenterology & Hepatology·Jacintha O'SullivanJohn V Reynolds
Jan 10, 2019·The New England Journal of Medicine·Christophe MarietteUNKNOWN Fédération de Recherche en Chirurgie (FRENCH) and French Eso-Gastric Tumors (FREGAT) Working Group
Jan 25, 2019·Annals of Surgery·Leonie R van der WerfUNKNOWN Dutch Upper GI Cancer Audit (DUCA) group
Sep 16, 2019·The Lancet Oncology·Melina ArnoldFreddie Bray
Sep 22, 2019·The Annals of Thoracic Surgery·Paul A CarrollGail E Darling