PMID: 24748434Apr 22, 2014Paper

Modern perspectives on numerical modeling of cardiac pacemaker cell

Journal of Pharmacological Sciences
Victor A MaltsevEdward G Lakatta


Cardiac pacemaking is a complex phenomenon that is still not completely understood. Together with experimental studies, numerical modeling has been traditionally used to acquire mechanistic insights in this research area. This review summarizes the present state of numerical modeling of the cardiac pacemaker, including approaches to resolve present paradoxes and controversies. Specifically we discuss the requirement for realistic modeling to consider symmetrical importance of both intracellular and cell membrane processes (within a recent "coupled-clock" theory). Promising future developments of the complex pacemaker system models include the introduction of local calcium control, mitochondria function, and biochemical regulation of protein phosphorylation and cAMP production. Modern numerical and theoretical methods such as multi-parameter sensitivity analyses within extended populations of models and bifurcation analyses are also important for the definition of the most realistic parameters that describe a robust, yet simultaneously flexible operation of the coupled-clock pacemaker cell system. The systems approach to exploring cardiac pacemaker function will guide development of new therapies such as biological pacemakers fo...Continue Reading


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Apr 11, 2015·Frontiers in Physiology·Rebecca A Capel, Derek A Terrar
Mar 6, 2015·Frontiers in Physiology·Yael YanivVictor A Maltsev
May 16, 2020·Frontiers in Pharmacology·Zsófia KohajdaNorbert Nagy
Dec 5, 2019·Biomedical Engineering Letters·Wilhelm von RosenbergDanilo P Mandic
Jun 14, 2018·Science Signaling·Kenta TsutsuiEdward G Lakatta

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