Modern therapeutic approaches for the treatment of malignant liver tumours.

Nature Reviews. Gastroenterology & Hepatology
Henrik PetrowskyPierre-Alain Clavien

Abstract

Malignant liver tumours include a wide range of primary and secondary tumours. Although surgery remains the mainstay of curative treatment, modern therapies integrate a variety of neoadjuvant and adjuvant strategies and have achieved dramatic improvements in survival. Extensive tumour loads, which have traditionally been considered unresectable, are now amenable to curative treatment through systemic conversion chemotherapies followed by a variety of interventions such as augmentation of the healthy liver through portal vein occlusion, staged surgeries or ablation modalities. Liver transplantation is established in selected patients with hepatocellular carcinoma but is now emerging as a promising option in many other types of tumour such as perihilar cholangiocarcinomas, neuroendocrine or colorectal liver metastases. In this Review, we summarize the available therapies for the treatment of malignant liver tumours, with an emphasis on surgical and ablative approaches and how they align with other therapies such as modern anticancer drugs or radiotherapy. In addition, we describe three complex case studies of patients with malignant liver tumours. Finally, we discuss the outlook for future treatment, including personalized approa...Continue Reading

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Citations

Mar 24, 2021·Cancer Treatment and Research Communications·Alessandro Rizzo, Giovanni Brandi
Apr 24, 2021·World Journal of Gastrointestinal Oncology·Ming-Cheng GuanTian Yang
May 15, 2021·Scientific Reports·Veturia ChiroiuCristian Rugină
Jul 17, 2021·Frontiers in Oncology·Hang LiJin-He Guo
Aug 24, 2021·Journal of Cellular and Molecular Medicine·Bahare ShokoohianMassoud Vosough
Sep 1, 2021·Journal of Biochemical and Molecular Toxicology·Masoud NajafiKeywan Mortezaee
Sep 18, 2021·The Journal of Experimental Medicine·Chris D HermannAchim Krüger
Jan 14, 2021·Oncology Research and Treatment·Dieter Koeberle, Ralph Fritsch

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Methods Mentioned

BETA
surgical resection
biopsy

Clinical Trials Mentioned

NCT02232932
NCT03494946
NCT02215889
NCT02597348
NCT03256981
NCT03101475
NCT03380130
NCT03033446
NCT02837029
NCT03099564

Software Mentioned

Global
FOXFIRE
IDEAL
SIRFLOX

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