Modes of Calcium Regulation in Ischemic Neuron

Indian Journal of Clinical Biochemistry : IJCB
Vineeta SinghVibha Pandey

Abstract

Calcium (Ca2+) dysregulation is a major catalytic event. Ca2+ dysregulation leads to neuronal cell death and brain damage result in cerebral ischemia. Neurons are unable in maintaining calcium homeostasis. Ca2+ homeostasis imbalance results in increased calcium influx and impaired calcium extrusion across the plasma membrane. Ca2+ dysregulation is mediated by different cellular and biochemical mechanism, which leads to neuronal loss resulting stroke/cerebral ischemia. A better understanding of the Ca2+ dysregulation might help in the development of new treatments in order to reduce ischemic brain injury. An optimal concentration of Ca2+ does not lead to neurotoxicity in the ischemic neuron. Intracellular Ca2+ act as a trigger for acute neurotoxicity and this cause induction of long-lasting processes leading to necrotic and/or apoptotic post-ischemic delayed neuronal death or of compensatory, neuroprotective mechanisms has increased considerably. Moreover, routes of ischemic Ca2+ influx to neurons, involvement of intracellular Ca2+ stores and Ca2+ buffers, spatial and temporal relations between ischemia-induced increases in intracellular Ca2+ concentration and neurotoxicity will further increase our understanding about underlyin...Continue Reading

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