Modest weight loss through a 12-week weight management program with behavioral modification seems to attenuate inflammatory responses in young obese Koreans

Nutrition Research
Ae Jin LeeSung Nim Han

Abstract

Obesity has been reported to impair immune functions and lead to low-grade long-term inflammation; however, studies that have investigated the impact of weight loss on these among the young and slightly obese are limited. Thus, we investigated the effect of a 12-week weight management program with behavioral modifications on cell-mediated immune functions and inflammatory responses in young obese participants. Our hypothesis was that weight loss would result in improved immune functions and decreased inflammatory responses. Sixty-four participants (45 obese and 19 normal weight) finished the program. Obese (body mass index ≥25) participants took part in 5 group education and 6 individual counseling sessions. Normal-weight (body mass index 18.5-23) participants only attended 6 individual sessions. The goal for the obese was to lose 0.5 kg/wk by reducing their intake by 300 to 500 kcal/d and increasing their physical activity. Program participation resulted in a modest but significant decrease in weight (2.7 ± 0.4 kg, P < .001) and lipopolysaccharide-stimulated interleukin-1β production (from 0.85 ± 0.07 to 0.67 ± 0.07 ng/mL, P < .05) in the obese. In the obese group, increase in phytohemagglutinin-stimulated interleukin-10 produ...Continue Reading

References

Sep 1, 1989·Journal of Immunological Methods·E BloemenaP T Schellekens
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Nov 1, 1996·International Immunology·J M GombertA Herbelin
Mar 17, 1999·Journal of the American Dietetic Association·D C NiemanO R Fagoaga
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A MartíJ A Martínez
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jens M BruunBjorn Richelsen
May 4, 2004·Nature Reviews. Immunology·Antonio La Cava, Giuseppe Matarese
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Dec 13, 2005·American Journal of Respiratory Cell and Molecular Biology·Joseph D BrainRamon M Molina
Dec 16, 2005·Obesity Surgery·Robert W O'RourkeAntony C Bakke
Mar 21, 2006·Obesity Surgery·John B Dixon, Paul E O'Brien
Oct 4, 2006·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Ricardo Cohen
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Sep 19, 2007·Journal of Internal Medicine·A W Ferrante
Feb 22, 2008·Immunology Letters·Barbara Maria ColomboMaria Pia Sormani
Aug 30, 2008·Autoimmunity Reviews·José C Crispín, George C Tsokos
Nov 11, 2008·Brain, Behavior, and Immunity·Giamila Fantuzzi
May 30, 2009·Metabolism: Clinical and Experimental·Krista A VaradyCarol L Braunschweig
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·A ViardotK Samaras
Aug 14, 2010·Mediators of Inflammation·Rosário Monteiro, Isabel Azevedo
Dec 4, 2010·Experimental Biology and Medicine·Erik A Karlsson, Melinda A Beck
Feb 26, 2011·Nutrition Reviews·Monica C Klempel, Krista A Varady
Mar 3, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S-M Kuo, M M Halpern

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here