Modifiable lifestyle factors and heart failure: A Mendelian randomization study

American Heart Journal
Sabine van OortSusanna C Larsson

Abstract

Lifestyle factors may be important targets in the prevention of heart failure. The current knowledge on the relationship between lifestyle factors and heart failure originates mostly from observational studies. The objective of this study was to investigate causal associations of multiple lifestyle factors with heart failure risk by using Mendelian randomization. We obtained summary statistics data for single nucleotide polymorphisms associated with the following 5 lifestyle factors at genome-wide significance in genome-wide association studies of European-descent individuals: smoking, alcohol consumption, coffee consumption, physical activity, and sleep duration. The corresponding data for heart failure were acquired from a genome-wide association study comprising 47,309 cases and 930,014 controls of European ancestry. For the primary analyses, we used the inverse-variance weighted method. Genetic predisposition to smoking initiation (ever smoked regularly) was robustly associated with a higher odds of heart failure (odds ratio: 1.28; 99% CI: 1.21-1.35). Genetically predicted longer sleep duration was associated with a lower odds of heart failure (odds ratio per hour/day: 0.73; 99% CI: 0.60-0.89). We found no associations of a...Continue Reading

Citations

Nov 19, 2020·Scandinavian Journal of Medicine & Science in Sports·Martin BahlsMarcus Dörr
Dec 6, 2020·Current Opinion in Lipidology·Susanna C Larsson
Mar 13, 2021·The American Journal of Clinical Nutrition·Elina Hyppönen, Ang Zhou
Mar 29, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Martin BahlsHansjörg Baurecht
Aug 23, 2021·European Journal of Epidemiology·Inge A T van de LuitgaardenJoline W J Beulens

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