Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro

Agents and Actions
A M Northover

Abstract

Endothelial cells lining guinea pig inferior venae cavae change shape when exposed to histamine, bradykinin, A23187 or platelet-activating factor (PAF) in vitro. Pre-treatment of the endothelium with isoprenaline or quin 2 significantly reduced the shape changes produced in response to histamine, bradykinin and A23187, but not those to PAF. Since both isoprenaline and quin 2 may reduce the concentration of cytoplasmic Ca++, the former by raising cyclic AMP (cAMP) levels and the latter by acting as a Ca++ buffer, the results provide further evidence for the involvement of Ca++ in the responses of large vein endothelial cells to inflammatory agents in vitro. The effects of pre-treating the endothelium with the histamine receptor-blockers mepyramine (H1) or cimetidine (H2), or the bradykinin receptor-blockers des-arg9[leu8] bradykinin (B1) or des-arg[Hyp3, Thi5,8,D-Phe7] bradykinin (B2) suggest that the response to histamine is both H1 and H2 receptor-mediated, while the response to bradykinin is only B2 receptor-mediated.

References

Aug 15, 1988·Biochemical and Biophysical Research Communications·M HirafujiY Ogura
Oct 1, 1987·The American Journal of Physiology·R Morgan-BoydA Hassid
Oct 14, 1987·Biochemical and Biophysical Research Communications·W W Lo, T P Fan
Nov 15, 1986·The Biochemical Journal·R H Ashley
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S F SteinbergJ P Bilezikian
Nov 1, 1984·The Journal of Pharmacy and Pharmacology·S Mohd Hidir, D A Lewis
Jan 1, 1982·Progress in Biophysics and Molecular Biology·J R BlinksF G Prendergast
Feb 27, 1980·Biochemical and Biophysical Research Communications·N L BaenzigerP R Becherer

❮ Previous
Next ❯

Citations

Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·P J FarmerP Sirois
May 1, 1994·Survey of Ophthalmology·K D Steinsapir, R A Goldberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.