Modification of a volume-overload heart failure model to track myocardial remodeling and device-related reverse remodeling.

ISRN Cardiology
Egemen TuzunBranislav Radovancevic

Abstract

Purpose. To provide an ovine model of ventricular remodeling and reverse remodeling by creating congestive heart failure (CHF) and then treating it by implanting a left ventricular assist device (LVAD). Methods. We induced volume-overload heart failure in 2 sheep; 20 weeks later, we implanted an LVAD and assessed recovery 11 weeks thereafter. We examined changes in histologic and hemodynamic data and levels of cellular markers of CHF. Results. After CHF induction, we found increases in LV end-diastolic pressure, LV systolic and diastolic dimensions, wall thickness, left atrial diameter, and atrial natriuretic protein (ANP) and endothelin-1 (ET-1) levels; β-adrenergic receptor (BAR) and dystrophin expression decreased markedly. Biopsies confirmed LV remodeling. After LVAD support, LV systolic and diastolic dimensions, wall thickness, and mass, and ANP and ET-1 levels decreased. Histopathologic and hemodynamic markers improved, and BAR and dystrophin expression normalized. Conclusions. We describe a successful sheep model for ventricular and reverse remodeling.

References

Mar 15, 2000·International Journal of Cardiology·J Niebauer
Feb 8, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·J WhicherL M Biasucci
Jan 28, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Egemen TuzunBranislav Radovancevic
Jun 23, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·O H FrazierKamuran A Kadipasaoglu

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Citations

Apr 24, 2015·Frontiers in Surgery·Cheyenne C S TsengSteven A J Chamuleau
Nov 26, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Gretel MonrealSteven C Koenig
Oct 31, 2018·International Journal of Molecular Sciences·Brian X WangCesare M N Terracciano

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Methods Mentioned

BETA
biopsy
biopsies
transmission electron microscopy

Software Mentioned

Sigma Scan Pro
HeartWare

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