Modification of accessory activity of peritoneal cells from Fasciola hepatica infected rats

Veterinary Immunology and Immunopathology
Diana T MasihJ M Casado

Abstract

The effect of Fasciola hepatica excretory-secretory antigen (ESA) was studied in the modulation of the accessory functions of peritoneal cells (PC) of rats infected with the parasite. PC rats infected with F. hepatica 7 and 14 days previously showed a marked decrease in phagocytic activity against Candida tropicalis (P < 0.007 and P < 0.004, respectively). The same effect was observed when the assay was carried out with PC from animals injected 7 days before with ESA (P < 0.001) including PC previously treated in vitro with ESA. To investigate the effect of ESA on the antigen presenting ability, PC of animals infected before transfer to syngeneic normal rats were stimulated in vitro with either F. hepatica whole antigen (FhWA), ESA or human serum albumin (HSA). Delayed type hypersensitivity (DTH) response to the different antigens studied over a 35 day period was negative in rats transferred with sensitised PC. When these animals were immunised with the corresponding antigen the DTH response became positive. A similar result was obtained in PC receptors from ESA inoculated rats and in vitro stimulated with FhWA or HSA. These data suggest that the alterations observed in the functions of peritoneal cells may, in part be due to t...Continue Reading

References

Jul 1, 1978·The Journal of Experimental Medicine·N Nogueira, Z A Cohn
Nov 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·L A CerviD T Masih
Jan 15, 1992·Veterinary Immunology and Immunopathology·N K RakhaP Jenkins
Feb 1, 1991·Biochemical Society Transactions·M HeffernanJ P Dalton
Nov 1, 1982·Veterinary Parasitology·C B Chapman, G F Mitchell
Feb 3, 1978·Science·G J Nossal

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Citations

Sep 11, 2004·The Journal of Parasitology·Elisabete SilvaMaria Silva
Apr 29, 2006·Journal of Veterinary Science·G GangaR L Sharma

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