PMID: 8590314Feb 1, 1995Paper

Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Staley A BrodJ T Phillips

Abstract

The effect of orally administered type 1 interferons on the severity of acute experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease, was examined by inoculation of Lewis rats with guinea pig myelin basic protein (GPMBP) and complete Freund's adjuvant. Rats were fed either rat species-specific or human recombinant type 1 interferon (IFN) or mock IFN daily for 7 days preceding immunization and for 21 days thereafter. There was a significant decrease in the clinical score and inflammatory foci in animals fed 5000 units IFN compared with mock-treated animals. There was a significant decrease in clinical score and number of inflammatory foci in spinal cord in animals fed orally 5000 units human recombinant IFN-alpha PO compared with SC 5000 units recombinant human IFN-alpha. Oral administration of type 1 interferon, as opposed to subcutaneous administration, inhibited the secretion of IFN-gamma from ConA-activated draining popliteal lymph node cells compared with mock-fed animals. These experiments demonstrate that acute EAE is more effectively inhibited by equivalent amounts of orally in contrast to parenterally administered IFN-alpha. These results suggest that type 1 IFNs are active by the oral rou...Continue Reading

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Citations

Jun 7, 2000·Pharmaceutical Science & Technology Today·M W Beilharz
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A BrodW J Riley
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W A Tompkins
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J M CumminsS Krakowka
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V Bocci
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P I MarcusM J Sekellick
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y SatohT Minagawa
Mar 25, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M G Tovey, C Maury
Oct 22, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y NagaoA Uemura
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Jul 4, 2016·Cytokine·Staley A Brod
Jan 28, 2010·Pharmaceuticals·Manfred W BeilharzJoseph M Cummins
Feb 5, 2005·American Journal of Veterinary Research·Joseph M CumminsChad G Thompson
Dec 18, 2002·Experimental Biology and Medicine·Staley A Brod
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Sep 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duncheng WangMark D Mannie

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