Modification of alpha-adrenergic responses of small arteries by altered PCO2 and pH

European Journal of Pharmacology
D L WiegmanP D Harris


Closed-circuit television microscopy was used to measure in vivo small artery (75--140 microns) and vein (105--230 microns) diameters to determine if changes in tissue PCO2 and/or pH would alter the microvascular responses to norepinephrine. Sprague-Dawley rats were anesthetized with a combination of urethane (800 mg/kg) and alpha-chloralose (60 mg/kg). The cremaster muscle with intact circulation and innervation was suspended by sutures in a 60-ml bath which contained a modified Krebs solution (31 degrees C) that was buffered by Tris of bicarbonate. There were four groups of animals with different combinations of bath PCO2 and pH: (1) PCO2 less than 10 mm Hg and pH = 7.2, (2) PCO2 less than 10 mm Hg and pH = 6.9, (3) PCO2 = 60--70 mm Hg and pH = 7.2, and (4) PCO2 = 60--70 MM Hg and pH = 6.9. The maximal responses of the small artery and vein to norepinephrine were similar for the four groups. The artery sensitivity to norepinephrine was significantly lower for group 4 when compared to groups 1, 2 and 3, but there was no effect on small vein sensitivity. Thus, the combination of decreased pH and increased PCO2 reduces small artery sensitivity to norepinephrine in the cremaster muscle of the rat.


Jan 1, 1996·Microsurgery·R J FrankenJ H Barker
Jul 1, 1982·Digestive Diseases and Sciences·W W La MorteL F Williams
May 1, 1980·Intensive Care Medicine·B FondP Auzépy
Feb 20, 2002·Acta Physiologica Scandinavica·V N YartsevD P Dvoretsky
Sep 1, 1982·Journal of Pharmacological Methods·J H ChristensenF Andreasen
Jul 17, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Selahattin OzmenKenan Atabay
Jan 1, 1988·Experimental Lung Research·E H Bronstein, R J Porcelli
Nov 14, 1997·The Journal of Surgical Research·P J MathesonR N Garrison
Aug 18, 2000·The Journal of Surgical Research·P J MathesonR N Garrison
Nov 1, 1986·The American Journal of the Medical Sciences·A O Davies
Apr 1, 1988·Journal of Endocrinological Investigation·A O Davies


Jul 1, 1976·Acta Physiologica Scandinavica·L Edvinsson, R Sercombe
Dec 28, 1976·Pflügers Archiv : European journal of physiology·C SteinhagenI Hosselmann
Mar 1, 1977·Clinical and Experimental Pharmacology & Physiology·M SmileyD Garlick
May 1, 1972·European Journal of Pharmacology·J M Atkinson, M J Rand
Sep 1, 1970·Circulation Research·T Yipintsoi, J B Bassingthwaighte

Related Concepts

Arterial System
Entire Vein
Muscle Innervation, Function
Norepinephrine, (+, -)-Isomer
Nerve Supply
Rats, Sprague-Dawley

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.