PMID: 1208631Sep 1, 1975Paper

Modification of avoidance behavior in 6-hydroxydopamine-treated rats by stimulation of central noradrenergic and dopaminergic receptors

Pharmacology, Biochemistry, and Behavior
L G Lenard, B Beer

Abstract

Rats showing reliable decrements in conditioned avoidance behavior after the intraventricular administration of 6-hydroxdopamine (6-HD) with pargyline pretreatment were given various dopaminergic and noradrenergic agonists. Intraventricular injections of DA or L-NE or intraperitoneal injections of apomorphine or L-DOPA reversed the avoidance decrements, often restoring performance to pre-6-HD-treatment levels. Furthermore, these agonists all produced behavior characteristic of activity in dopaminergic neurons. Clonidine, a noradrenergic agonist, also reversed avoidance decrements, but did not produce behavior characteristic of stimulation of dopaminergic neurons in the brain. Pretreatment with spiroperidol, a dopaminergic receptor blocker, prevented the recovery induced by all agonists, although clonidine-induced recovery was affected least. The results are discussed in terms of possible separate roles for dopaminergic and noradrenergic neurons in the brain in avoidance behavior.

References

Sep 1, 1975·Pharmacology, Biochemistry, and Behavior·L G Lenard, B Beer
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·S Ahlenius, J Engel
Feb 1, 1968·The Journal of Pharmacy and Pharmacology·K D Krantz, L S Seiden
May 1, 1970·Life Sciences·N E AndénT Svensson
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·L BarnesV G Longo
Jan 1, 1972·European Journal of Pharmacology·K M Taylor, R Laverty
Jul 1, 1972·European Journal of Pharmacology·R Schoenfeld, N Uretsky
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt
Jan 1, 1966·Psychopharmacologia·H Corrodi, L C Hanson
Dec 1, 1964·International Journal of Neuropharmacology·C C CHANG

❮ Previous
Next ❯

Citations

Oct 1, 1980·Neurochemical Research·F V DeFeudis
Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·R J Carey, S Kenney
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·T P Oei, M G King
Jan 1, 1981·Medicinal Research Reviews·S Fielding, H Lal
Jan 1, 1981·Acta Neurologica Scandinavica. Supplementum·C Mondadori
Jan 1, 1978·The Journal of International Medical Research·A Delini-StulaA Vassout

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.