PMID: 3761197Oct 1, 1986Paper

Modification of behavioral effects and biodisposition of phencyclidine in rats by ammonium chloride

The Journal of Pharmacology and Experimental Therapeutics
B F ThomasB R Martin

Abstract

The ability of ammonium chloride (NH4Cl) treatment to alter the pharmacological effects and biodisposition of phencyclidine (PCP) was investigated in rats. Either a single gavage of NH4Cl (2.5 mEq/kg) or six hourly gavages with either 2.5 or 5.0 mEq/kg of NH4Cl decreased urinary pH to approximately 5.5 at the 7-hr time point. A single gavage with NH4Cl (2.5 mEq/kg) failed to alter the time course of rotarod performance in rats that had been treated 45 min earlier with either 10, 25 or 50 mg of PCP per kg (p.o.). A treatment regimen of six hourly gavages of NH4Cl (5.0 mEq/kg) proved to be highly toxic, whereas gavages with 2.5 mEq/kg did not produce overt effects. Six hourly treatments with the lower dose of NH4Cl did not alter motor impairment induced by oral doses of 10 and 25 mg/kg of PCP but did diminish that produced by 50 mg/kg. This treatment regimen also produced a slight reduction in the time course of motor dysfunction in rats receiving an i.v. injection of either 5, 10 or 15 mg/kg of PCP. The biodisposition of orally administered [3H]PCP (50 mg/kg) was altered by six hourly gavages of 2.5 mEq/kg of NH4Cl in that urinary excretion of [3H]PCP was increased whereas concentrations in kidney, lung and brain were significan...Continue Reading

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