Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids

Neurochemistry International
Gerard MuntanéIsidre Ferrer

Abstract

Transgenic mice expressing both wild mouse alpha-synuclein and the Parkinson's disease associated A53T mutated human alpha-synuclein were subjected to long-term diets impoverished in n-3 or diets impoverished in n-3 and supplemented with docosahexaenoic acid (DHA) for 6 months. Transgenic mice evidenced mild phenotype characterized by increased total alpha-synuclein expression, truncated alpha-synuclein forms, and abnormal solubility and aggregation, in the absence of Lewy bodies and neurites, and lack of apparent neuronal loss, astrocytosis and microgliosis. These diets produced a reduction in the content of linolenic, n-3 docosapentaenoic and total polyunsaturated fatty acids, leading to significantly lower double bond and peroxidizability indexes as well as to lower protein oxidative damage, with no effects in alpha-synuclein expression and with no modifications in the number of cortical astrocytes and microglial cells. The present results show that diets may modify brain lipid composition and susceptibility to oxidative damage that do not interfere with phenotype in models with a genetic susceptibility to develop alpha-synucleinopathy.

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Citations

Jan 10, 2019·Cells·Helena XicoyGerard J M Martens
Nov 11, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Mar 4, 2020·Nutritional Neuroscience·Peng Li, Cai Song
May 24, 2019·Frontiers in Cellular Neuroscience·Natalia P AlzaGabriela A Salvador
Nov 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pascual TorresVictòria Ayala
Mar 19, 2011·Ageing Research Reviews·Mélanie BousquetFrancesca Cicchetti
Aug 11, 2012·Pharmacology, Biochemistry, and Behavior·Berrak YetimlerEwa Jakubowska-Doğru

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