Modification of buccal drug delivery following pretreatment with skin penetration enhancers

Journal of Pharmaceutical Sciences
Joseph A NicolazzoB C Finnin

Abstract

The effect of the lipophilic skin penetration enhancers octisalate (OS), padimate O (PO), and Azone (AZ) on in vitro buccal permeability was assessed using caffeine (CAF), estradiol (E2), and triamcinolone acetonide (TAC) as model permeants. Buccal permeability was assessed in modified Ussing chambers, through both untreated porcine buccal mucosa and mucosa pretreated with an enhancer (5% w/v in 95% v/v ethanol) or ethanol alone. To ensure sink conditions were present, E2 permeability experiments were also performed with bovine serum albumin (BSA) 4% in the receptor solution. Mucosa-buffer partition studies were performed to determine the effect of enhancer pretreatment on the log mucosa-buffer partition coefficient (logK) of E2 and TAC. CAF permeability was only increased following pretreatment with ethanol 95%. E2 buccal transport was not altered following OS pretreatment, but was reduced by 26.3% with PO pretreatment and 67.6% with AZ pretreatment. Similar results were obtained with BSA 4% in the receptor solution. The logK of E2 was increased 1.4-fold and 2.2-fold in PO- and AZ-pretreated tissues, respectively, suggesting that the reduction in flux caused by PO and AZ may have been due to enhanced E2 tissue retention. The e...Continue Reading

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Nov 7, 2003·Journal of Pharmaceutical Sciences·Joseph A NicolazzoBarrie C Finnin

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Citations

Feb 3, 2009·Pharmaceutical Research·Amit KokateBhaskara R Jasti
May 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph A NicolazzoBarrie C Finnin
Jun 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph A NicolazzoBarrie C Finnin
May 4, 2011·AAPS PharmSciTech·Upendra Dilip KulkarniBhaskara Jasti
Mar 25, 2006·Drug Development and Industrial Pharmacy·Miriam López-CervantesEnrique Angeles-Anguiano
Nov 22, 2005·Expert Opinion on Drug Delivery·John D Smart
Feb 18, 2014·Journal of Pharmaceutical Sciences·Emil Meng-LundJoseph A Nicolazzo
Apr 2, 2014·Journal of Pharmaceutical Sciences·Thiago CaonJoseph A Nicolazzo
Sep 17, 2010·Journal of Pharmaceutical Sciences·Lars B HeemstraJoseph A Nicolazzo
May 2, 2009·Journal of Pharmaceutical Sciences·Maria L A D LestariBarrie C Finnin
May 26, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viralkumar F PatelMarc B Brown
Apr 3, 2012·International Journal of Pharmaceutics·V De CaroL I Giannola
Jan 12, 2010·International Journal of Pharmaceutics·Yi-Hung TsaiPao-Chu Wu
Dec 12, 2007·British Journal of Clinical Pharmacology·Nina OtbergJürgen Lademann
Jun 1, 2014·International Journal of Pharmaceutics·Mohammed SattarMajella E Lane
Dec 7, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Javier O Morales, Jason T McConville
Oct 30, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wenhua LiuYouxin Li
Apr 24, 2018·Therapeutic Delivery·Aroonsri PripremCheardchai Soontornpas
Aug 29, 2013·Journal of Veterinary Pharmacology and Therapeutics·W BayldonP C Mills
Oct 26, 2018·Pharmaceutics·Cristina PadulaPatrizia Santi
Nov 3, 2020·Chemical & Pharmaceutical Bulletin·Kenji SugibayashiHiroaki Todo
Apr 20, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eva ŠnejdrováKlára Konečná

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