PMID: 44984Jan 1, 1979

Modification of curarization after acute administration of 2 antiepileptic drugs

Annales de l'anesthésiologie française
M C Blanc-BimarP Bouyard


In rats anaesthetised with sodium pentobarbital the previous administration of a single dose of an anti-epileptic agent (carbamazepine or sodium valproate) significantly increases the curarising action of two short-action curare-like agents--pancuronium bromide and fazadinium bromide. It seems that this potentialisation of curare action might be the result of either a pharmacokinetic interference (competion for plasma protisen receptor sites), or due to a summation of depressor actions at the neuromuscular level, especially through changes in the levels of GABA and/or cAMP.

Related Concepts

Cyclic AMP, (R)-Isomer
Neuromuscular Nondepolarizing Agents
Pancuronium Curamed
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Drug Augmentation
Pyridinium Compounds
Carbamazepine Sulfate (2: 1)

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