PMID: 16840006Oct 1, 1992Paper

Modification of erythrocyte membrane lipid composition induced by a single intravenous infusion of phospholipid-triacylglycerol emulsions in man

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
W DahlanY A Carpentier


The study aimed to investigate whether, during short term infusion of lipid emulsions in man, red blood cell (RBC) membrane lipid composition was altered and RBC-free cholesterol (FC) could serve as a source of FC accumulated in the plasma. 3 normal subjects were infused intravenously with either 10% Intralipid [10% IL; PL:triglyceride (TG) weight ratio of 0.12] at the rates of 0.1, 0.2 and 0.3 g (providing PL intakes of 12, 24, 36, respectively) or with 30% Intralipid (30% IL; PL:TG ratio of 0.04) at the rate of 0.3 g (providing 12 mg Infusion of 10% IL at a slow rate and 30% IL at a high rate caused no change in RBC and plasma FC content. However, 10% IL infusion at intermediate and high rates induced a significant decrease in RBC-FC: PL ratio. This change was still present at 18 h after the cessation of high rate infusion. RBC-FC: PL ratio and plasma PL measured during infusion were significantly correlated (r = -0.87, p < 0.001). FC efflux from RBC appears to contribute to the rise in plasma FC. This study indicates that the excessive amount of PL present as liposomes in some intravenous lipid emulsions can alter erythrocyte membrane lipid composition.


Jan 1, 1979·Canadian Journal of Biochemistry·W C BreckenridgeA Kuksis
Dec 1, 1979·The Journal of Clinical Investigation·E GriffinA Angel
Jan 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S M Innis
Apr 1, 1989·Metabolism: Clinical and Experimental·M Aviram, R J Deckelbaum
Dec 1, 1988·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·G KakisW C Breckenridge
Feb 8, 1985·Biochimica Et Biophysica Acta·E GranotG Bengtsson-Olivecrona
Jan 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·G Kakis, A Kuksis
May 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·A Wretlind
Apr 1, 1983·Biochemical Medicine·M GotoY Nozawa
Feb 23, 1982·Biochimica Et Biophysica Acta·P OttU Brodbeck
Oct 1, 1958·The American Journal of Physiology·M FRIEDMAN, S O BYERS
Jun 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Y A Carpentier

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Sep 14, 1995·Biochimica Et Biophysica Acta·T HajriC Lutton
Jan 1, 1996·Progress in Lipid Research·A C BachA Frey
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ch SimoensY A Carpentier
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F KalfarentzosK Alexopoulos
Sep 1, 1996·The British Journal of Surgery·J S SamraK N Frayn

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