PMID: 2505298Jan 1, 1989Paper

Modification of ethanol effects by bicuculline: genotype-dependent responses and inheritance

Psychopharmacology
T J Phillips, B C Dudek

Abstract

Genetic influences on the interaction between ethanol (ETOH) and gamma-aminobutyric acid (GABA) neurotransmitter systems were evaluated with a survey of responses to coadministration of ETOH and a GABA antagonist, bicuculline, in a battery of inbred mouse strains. The selectively bred ETOH-sensitive Long-Sleep (LS) mice, the relatively ETOH-resistant Short-Sleep (SS) mice, and a genetically heterogeneous stock (GHS) were also evaluated. The effect of bicuculline on ETOH-induced sedation, hypothermia, and blood ethanol content upon recovery from sedation was assessed. Inheritance of these responses was also examined using F1 hybrids. The effect of bicuculline on ETOH-produced narcosis varied widely among stocks and included antagonism, potentiation, and no effect. Changes in ETOH-induced narcosis produced by bicuculline were accompanied by changes in blood ethanol concentrations consistent with an hypothesis of altered central nervous system sensitivity to ETOH. Knowledge of a strain's seizure susceptibility to the GABA antagonist or of its sensitivity to the hypnotic effects of ETOH were of no predictive value in estimating the outcome of coadministration studies, suggesting at least partially separate genetic influences on eac...Continue Reading

References

Feb 4, 1977·Biochimica Et Biophysica Acta·M K Ticku, R W Olsen
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P D SuzdakS M Paul
Jan 1, 1989·Psychopharmacology·B C Dudek, T J Phillips
Feb 10, 1984·European Journal of Pharmacology·D W GallagerA B Malcolm
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P FerreroE Costa
Dec 1, 1983·Pharmacology, Biochemistry, and Behavior·M M SchweriP Skolnick
Apr 22, 1983·European Journal of Pharmacology·A MartzR A Harris

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Citations

Sep 15, 1989·Experientia·T J PhillipsJ C Crabbe
Mar 1, 1991·Pharmacology, Biochemistry, and Behavior·B J BowersJ M Wehner
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·J M WehnerL A Waltrip
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D Bustamante, H F Miranda

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