Modification of formalin-induced nociception by different histamine receptor agonists and antagonists

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
D Farzin, Farnaz Nosrati

Abstract

The present study evaluated the effects of different histamine receptor agonists and antagonists on the nociceptive response in the mouse formalin test. Intracerebroventricular (20-40 microg/mouse i.c.v.) or subcutaneous (1-10 mg/kg s.c.) injection of HTMT (H(1) receptor agonist) elicited a dose-related hyperalgesia in the early and late phases. Conversely, intraperitoneal (20 and 30 mg/kg i.p.) injection of dexchlorpheniramine (H(1) receptor antagonist) was antinociceptive in both phases. At a dose ineffective per se, dexchlorpheniramine (10 mg/kg i.p.) antagonized the hyperalgesia induced by HTMT (40 mug/mouse i.c.v. or 10 mg/kg s.c.). Dimaprit (H(2) receptor agonist, 30 mg/kg i.p.) and ranitidine (H(2) receptor antagonist, 20 and 40 mg/kg i.p.) reduced the nociceptive responses in the early and late phases. No significant change in the antinociceptive activity was found following the combination of dimaprit (30 mg/kg i.p.) with ranitidine (10 mg/kg i.p.). The antinociceptive effect of dimaprit (30 mg/kg i.p.) was prevented by naloxone (5 mg/kg i.p.) in the early phase or by imetit (H(3) receptor agonist, 25 mg/kg i.p.) in both early and late phases. The histamine H(3) receptor agonist imetit was hyperalgesic following i.p. a...Continue Reading

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Citations

Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Lindsay B Hough, Frank L Rice
Mar 6, 2009·Pakistan Journal of Biological Sciences : PJBS·A MojtahedinA Zanbouri
Jun 28, 2007·Expert Opinion on Investigational Drugs·Maikel WijtmansIwan de Esch
May 12, 2009·Drug Discovery Today·Mark J GemkowDavid Hallett
Oct 15, 2008·Peptides·Richard J Bodnar
Jul 26, 2012·Biochemical and Biophysical Research Communications·Devavani ChatterjeaTijana Martinov
May 16, 2009·Expert Opinion on Therapeutic Patents·Róbert Kiss, György M Keseru
Jan 17, 2020·Frontiers in Neuroscience·Lidia BravoJuan Antonio Micó

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