Modification of glucose metabolism in brain tumors by using cervical spinal cord stimulation

Journal of Neurosurgery
B ClavoJose L Carreras

Abstract

In previous studies the authors have shown potential increases in locoregional blood flow and oxygenation in tumors by using electrical cervical spinal cord stimulation (SCS). In the present report they demonstrate the effect of cervical SCS on brain tumor metabolism, as assessed using [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Cervical devices were inserted in 11 patients who had high-grade gliomas, six of which had recurred. While the SCS device was deactivated, each patient underwent an initial FDG-PET study to clarify the clinical status. A second FDG-PET study was performed later the same day while the stimulation device was activated to determine the effect of cervical SCS on glucose metabolism. All 11 patients were invaluable for this PET study. Basal glucose metabolism was higher in the tumor than in the peritumoral areas (p = 0.048). There was a significant increase in glucose uptake during cervical SCS in both the tumor (p = 0.035) and the peritumoral (p = 0.001) areas, with measured increases of 43 and 38%, respectively. The estimated potential maximal residual activity of the first FDG dose's contribution to the activity on the second scan was 18.5 +/- 1% or less. This PET study is the first in ...Continue Reading

Associated Clinical Trials

Jun 5, 2013·Bernardino Clavo, MD, PhD

References

Jan 1, 1989·Journal of Pineal Research·R S DonhamM H Stetson
Jun 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·R C TallisJ S Garfield
Jun 15, 1994·International Journal of Radiation Oncology, Biology, Physics·R RamplingP Workman
Oct 23, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M C HulshofD González González
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D R CollingridgeJ P Knisely
Jul 6, 2000·Journal of Neurosurgery·O Sagher, D L Huang
Jan 25, 2002·Journal of Neurosurgery·Bernardino ClavoMartina Günderoth
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Rafal TarnawskiTeresa Krupska
Apr 30, 2002·Experimental Cell Research·Robert SternBent Formby
Feb 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Bénédicte F JordanBernard Gallez
Jun 21, 2003·Journal of Neurosurgery·Bernardino ClavoMaria A Hernández

❮ Previous
Next ❯

Citations

Dec 18, 2007·Autonomic Neuroscience : Basic & Clinical·Mingyuan WuRobert D Foreman
Jun 3, 2008·Neurological Research·Bernardino ClavoJose L Carreras
Jun 15, 2007·Pain Practice : the Official Journal of World Institute of Pain·Jose De AndrésV Villanueva

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.