Modification of hippocampal circuitry by adult neurogenesis.

Developmental Neurobiology
Juan SongHongjun Song

Abstract

The adult hippocampus is one of the primary neural structures involved in memory formation. In addition to synapse-specific modifications thought to encode information at the subcellular level, changes in the intrahippocampal neuro-populational activity and dynamics at the circuit-level may contribute substantively to the functional capacity of this region. Within the hippocampus, the dentate gyrus has the potential to make a preferential contribution to neural circuit modification owing to the continuous addition of new granule cell population. The integration of newborn neurons into pre-existing circuitry is hypothesized to deliver a unique processing capacity, as opposed to merely replacing dying granule cells. Recent studies have begun to assess the impact of hippocampal neurogenesis by examining the extent to which adult-born neurons participate in hippocampal networks, including when newborn neurons become engaged in ongoing network activity and how they modulate circuit dynamics via their unique intrinsic physiological properties. Understanding the contributions of adult neurogenesis to hippocampal function will provide new insight into the fundamental aspects of brain plasticity, which can be used to guide therapeutic i...Continue Reading

References

Apr 22, 1986·The Journal of Comparative Neurology·B J ClaiborneW M Cowan
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Apr 9, 1999·Nature Neuroscience·E GouldT J Shors
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
Feb 26, 2000·Science·F H Gage
Jul 13, 2000·Molecular Psychiatry·B L JacobsF H Gage
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Nov 19, 2003·The Journal of Comparative Neurology·Golo KronenbergGerd Kempermann
Dec 6, 2003·The European Journal of Neuroscience·Klaus FabelTheo D Palmer
Feb 24, 2004·Journal of Hematotherapy & Stem Cell Research·Eyleen Lay Keow GohHongjun Song
Mar 9, 2004·Neuron·Arturo Alvarez-Buylla, Daniel A Lim
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda S OverstreetMarcelo Rubinstein
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Jun 15, 2004·Nature Neuroscience·Günter U HöglingerEtienne C Hirsch
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 24, 2004·The Journal of Comparative Neurology·Bettina SeriArturo Alvarez-Buylla
Jan 18, 2005·Neuroscience·J S SnyderJ M Wojtowicz
Jan 28, 2005·The European Journal of Neuroscience·Elodie Bruel-JungermanClaire Rampon
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Sep 8, 2005·Current Opinion in Neurobiology·Dengke K MaHongjun Song
Sep 20, 2005·Experimental Neurology·Sebastian JessbergerGerd Kempermann
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hongjun SongJosef Bischofberger
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Jan 20, 2006·Hippocampus·Benedetta LeunerTracey J Shors
Jan 21, 2006·Hippocampus·Jennifer L Warner-Schmidt, Ronald S Duman
Feb 24, 2006·Nature Reviews. Neuroscience·Pierre-Marie LledoMatthew S Grubb
Apr 14, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linda S Overstreet-WadicheGary L Westbrook
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Juan M EncinasGrigori Enikolopov
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elodie Bruel-JungermanSerge Laroche
Jul 11, 2006·Neurobiology of Learning and Memory·Sung Kun ChunMin Whan Jung
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D SaxeMichael R Drew
Nov 23, 2006·Trends in Neurosciences·Shaoyu GeHongjun Song
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victor Ramirez-AmayaCarol A Barnes

❮ Previous
Next ❯

Citations

Feb 13, 2014·Nature Communications·L M RangelL K Quinn
Nov 26, 2013·Molecular Brain·Paula M HeronTimothy S McClintock
Jan 24, 2016·Brain Research·Deana M AppleErzsebet Kokovay
Jan 29, 2014·Epilepsy & Behavior : E&B·Michael S Hester, Steve C Danzer
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Feifei WangXinyu Zhao
Jul 29, 2016·Neurogenesis·Brent AsricanChay T Kuo
Dec 22, 2015·Molecular Neurobiology·Musaad A AlshammariFernanda Laezza
May 23, 2012·Developmental Neurobiology·Perry F Bartlett, Benedikt Berninger
Mar 22, 2016·Frontiers in Neuroendocrinology·Maya OpendakElizabeth Gould
Apr 11, 2012·Developmental Neurobiology·Matteo Bergami, Benedikt Berninger
Jan 3, 2013·Addiction Biology·Olivier DeschauxChitra D Mandyam
Jul 11, 2013·Neural Plasticity·Hideo HagiharaTsuyoshi Miyakawa
Dec 3, 2014·Brain Research·Parizad M Bilimoria, Beth Stevens
Dec 6, 2014·Experimental Neurology·Sloka S IyengarHelen E Scharfman
Jan 4, 2017·Neurobiology of Learning and Memory·Adejoke Y OnaolapoPolycarp U Nwoha
Dec 12, 2018·Human Gene Therapy Methods·Lucia SchoderboeckStephanie Hughes
Nov 19, 2015·Frontiers in Neuroscience·Francisco Aboitiz, Juan F Montiel
Sep 28, 2017·Cell and Tissue Research·Christina CataveroJuan Song
Apr 13, 2020·Molecular Biology Reports·Seyedeh Nahid FotuhiMahnaz Talebi
Sep 9, 2017·Scientific Reports·Nirnath SahHenriette van Praag
Jun 23, 2019·Nature Communications·Shawn F SorrellsArturo Alvarez-Buylla
Nov 22, 2016·Journal of Neuroscience Research·Natalie C Tronson, Katie M Collette
Sep 15, 2018·Neurotoxicity Research·Macarena S ArrázolaMarie-Christine Miquel
Jan 29, 2019·Frontiers in Cellular Neuroscience·Christina Koester-HegmannEdith M Schneider Gasser
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·N V BobkovaG T Sukhikh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.