Sep 1, 1990

Modification of human atrioventricular nodal function by selective atrioventricular nodal artery catheterization

P J WangP L Friedman


The hypothesis that human atrioventricular (AV) nodal function can be modulated selectively with a new technique of AV nodal artery catheterization was tested in eight subjects referred for diagnostic cardiac catheterization or electrophysiological studies. Three patients had no history of arrhythmias. Three patients had supraventricular tachycardia (SVT) due to reentry confined to the AV node (AVNRT). One patient had SVT due to reentry over a concealed AV bypass tract (AVRT-CBT), and one patient had nonsustained ventricular tachycardia. In each subject, sinus cycle length, AH interval, HV interval, AV nodal effective refractory period (AVN-ERP), and Wenckebach paced cycle length were measured in a control state. A flexible infusion catheter was then positioned selectively in the AV nodal artery of each subject. Through this catheter, a constant infusion of 0.1 mg/min procainamide at a flow rate of 0.125 ml/min (n = 1) or 50 micrograms/min acetylcholine at a flow rate of 0.25 ml/min (n = 4) was administered. Electrophysiological parameters were determined again during selective AV nodal artery drug infusion and during infusion of saline at identical rates. Two subjects developed transient AV nodal block during selective AV noda...Continue Reading

Mentioned in this Paper

Nonsustained Ventricular Tachycardia
Supraventricular Tachycardia
Crista Terminalis Branch of Sinoatrial Nodal Artery
Sinus - General Anatomical Term
Cardiac Catheterization Procedures
Atrioventricular Block
Refractory Period
Procainamide Measurement
Cardiac Conduction System

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