PMID: 6966221Feb 1, 1980Paper

Modification of human serum albumin binding of methotrexate by folinic acid and certain drugs used in cancer chemotherapy

European Journal of Clinical Pharmacology
P CoassoloC Briand

Abstract

The binding of methotrexate (MTX) and citrovorum factor (CF) to human serum albumin (HSA) was investigated. The affinity constant for MTX was 820 M-1, with 2 binding sites, and for CF 2340 M-1, with 1.5 binding sites. MTX and CF, which are used together in high dose therapy, compete for HSA binding. Competition for HSA binding between MTX and adriamycin, bleomycin and cyclophosphamide, drugs often used in association with MTX in cancer chemotherapy, was also demonstrated. The clinical importance of such competition depends on the drug/protein concentration ratio which is extremely variable.

References

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Citations

May 1, 1982·Clinical and Experimental Pharmacology & Physiology·J W Paxton
Dec 8, 2004·Critical Reviews in Oncology/hematology·E GroningerS S N de Graaf
Jan 11, 2017·Luminescence : the Journal of Biological and Chemical Luminescence·Li-Yang ChengYan-Jun Hu
Sep 1, 1982·Journal of Clinical Ultrasound : JCU·P S DunnerL E Nochomovitz
Jul 1, 1981·Angiology·J Hladovec, F De Clerck
Jan 1, 1985·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E BetzT Strohschneider
Apr 12, 2008·Journal of Oral Science·Zahed Mohammadi, Shahriar Shahriari
Dec 20, 2013·Journal of Oral Science·Seyedmohsen HasheminiaMorteza Rajabzadeh
Jun 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·O DelerueP Devos
Jun 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·E BescansaM Viñals
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A Bernard, E Bruera
Jan 23, 2021·RSC Medicinal Chemistry·Vítor YangNuno Vale

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