Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts

Transplantation
A S ChongJ W Williams

Abstract

Vigorous antibody-mediated responses prevent the successful engraftment of hamster hearts transplanted into Lewis rats. Early antibody responses mediating acute rejection of the xenograft are T cell-independent and resistant to the T-cell immunosuppressant, cyclosporine (CsA). Immunosuppression with the combination of leflunomide plus CsA completely prevents xenograft rejection, but when such immunosuppression is stopped the hamster heart is rejected by a process that we term late xenograft rejection. We report here on some of the immunological features of late xenograft rejection. Lewis rats transplanted with hamster hearts were treated with leflunomide (5 mg/kg/day by gavage) for 14-21 days and CsA (20 mg/kg/day by gavage) continuously from the day of transplant. Serum was harvested and the functional activities of the xenoreactive antibodies were quantitated by in vivo passive transfer of sera, flow cytometry, in vitro C3 deposition assays, and Western blotting. CsA alone prevented late xenograft rejection and the accompanying production of xenoreactive antibodies. The xenoreactive antibodies accompanying acute or late xenograft rejection were predominantly IgM, but only serum from rats undergoing acute xenograft rejection w...Continue Reading

References

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Citations

Mar 27, 2001·Transplantation Proceedings·J WooR Buelow
Apr 18, 2002·Transplantation Proceedings·D G MollevíJ Jaurrieta
Apr 18, 2002·Transplantation Proceedings·M Morell GinestàE Jaurrieta
Dec 16, 1998·Xenotransplantation·H Auchincloss
Nov 1, 2008·Transplant Immunology·Jean-Paul Dehoux, Pierre Gianello
Oct 13, 2017·International Journal of Molecular Sciences·Rossella TalottaDaria Trabattoni
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y LinF H Bach
Aug 29, 2000·Xenotransplantation·D V Cramer
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cody A KochJeffrey L Platt

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