Abstract
The staphylococcal enterotoxins have been termed superantigens based on their ability to stimulate polyclonal proliferative responses of murine and human T lymphocytes expressing particular T-cell receptor V beta gene products. Certain of these toxins have been shown both to activate and to induce anergy in reactive T cells. Staphylococcal enterotoxin B is known to interact with murine T cells bearing V beta 3, -7, -8.1, -8.2, -8.3, and -17. In BALB/c mice V beta 3+ and V beta 17+ T cells are deleted; V beta 7+ T cells are low in frequency. BALB/c mice sensitized to ovalbumin via the skin and airways develop immediate hypersensitivity including IgE/IgG1 antiovalbumin antibodies, immediate cutaneous reactivity to ovalbumin and, increased airway responsiveness. In both in vitro and in vivo studies, the development of these responses has been associated with the V beta 8+ subset of T cells and controlled by V beta 2 + T cells. In view of the central role of V beta 8+ T cells in these responses, we tested the effects of staphylococcal enterotoxin B on the development of immediate hypersensitivity in this system. Intradermal injection of staphylococcal enterotoxin B prevented the development of these responses in the absence of a ma...Continue Reading
References
Oct 1, 1978·Infection and Immunity·M P LangfordH M Johnson
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H RenzE W Gelfand
Mar 1, 1992·The Journal of Clinical Investigation·G L LarsenE W Gelfand
Mar 1, 1992·International Immunology·O RottB Fleischer
Jun 1, 1992·The Journal of Allergy and Clinical Immunology·H RenzE W Gelfand
Jan 17, 1991·Nature·Y Kawabe, A Ochi
Aug 1, 1990·The Journal of Experimental Medicine·J F GauchatJ E de Vries
Mar 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R E O'HehirJ R Lamb
Jun 11, 1991·International Immunology·F D FinkelmanI M Katona
Aug 1, 1991·European Journal of Immunology·H R MacDonaldR K Lees
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R E O'Hehir, J R Lamb
May 11, 1990·Science·P Marrack, J Kappler
Oct 1, 1990·The Journal of Experimental Medicine·B L RellahanL A Matis
Jan 13, 1989·Cell·J WhiteP Marrack
Feb 1, 1989·Immunological Reviews·C A JanewayS Buxser
Apr 1, 1989·The Journal of Experimental Medicine·D VercelliR S Geha
Jan 1, 1989·Infection and Immunity·D J FastR D Nelson
Mar 1, 1989·Journal of Clinical Immunology·D Vercelli, R S Geha
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J PèneJ Banchereau
Sep 1, 1988·The Journal of Experimental Medicine·D A Lebman, R L Coffman
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F D FinkelmanW E Paul
Oct 1, 1984·Clinical Immunology and Immunopathology·S E CalvanoP Dineen
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·J SalogaE W Gelfand
Jan 1, 1993·The Journal of Clinical Investigation·J SalogaE W Gelfand
Apr 1, 1993·The Journal of Experimental Medicine·H RenzE W Gelfand
Citations
Jun 1, 1997·The Journal of Clinical Investigation·S W Dow, T A Potter
Feb 17, 1999·The British Journal of Dermatology·W C Noble
Jun 20, 1998·Clinical Microbiology Reviews·D G Baker