PMID: 8739048May 1, 1996

Modification of inositol 1,4,5-trisphosphate concentration of human erythrocytes under "in vivo" physiological conditions

Biochemistry and Molecular Biology International
M P PiacentiniA Accorsi

Abstract

The concentration of inositol 1,4,5-trisphosphate (InsP3) in erythrocytes from volunteers has been found to modify following strenuous physical exercise. The basal value was almost regained within some 75 min after the completion of the effort. The concurrent variations of pH and blood lactate have also been evaluated. Our results represent, to our knowledge, the first evidence of in vivo induced intraerythrocyte InsP3 modification. They reinforce the idea of the participation of its precursor phosphatidylinositol 4,5-bisphosphate (PtdIns4,5-P2) in red bood cell shape regulation by contributing to the interactions between membrane and cytoskeleton components.

Related Concepts

Erythrocytes
Hydrogen-Ion Concentration
Hydrolysis
Lactates
Exercise, Isometric
Inositol 1,4,5-Trisphosphate
Phosphatidylinositol Phosphates
Phosphatidylinositol 4,5-Diphosphate
Lactate

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