Modification of late dermal necrosis in the pig by treatment with multi-wavelength light

The British Journal of Radiology
M RezvaniE M Whitehouse

Abstract

Low-level light from a multi-wavelength light source has been used to prevent late X-ray-induced dermal necrosis in the pig. Skin fields, measuring 4 cm x 4 cm on the flank, were irradiated with graded doses of X rays and the incidence of late dermal necrosis at 10-16 weeks after irradiation was scored. The control skin sites were irradiated only with 250 kV X rays but the test skin sites were subsequently exposed to low-level light. Local light exposure was from an array of gallium aluminium arsenide diodes, which produced wavelengths of 660, 820, 880 and 950 nm, pulsating at 5 kHz. Light treatment was given three times a week, from 6-16 weeks after X irradiation. Each treatment session was 1 min, which was equivalent to energy density of 1.08 Jcm-2. Light treatment increased the ED50, the dose which causes dermal necrosis in 50% of the irradiated skin fields, from 20.10 +/- 0.12 Gy to 21.94 +/- 0.30 Gy. This difference, although small, was highly significant (p < 0.001) and was equivalent to a dose modification factor (DMF) of 1.09. The effect of light treatment was minimal at incidence levels of less than the 50% but greater at higher levels of effect. These findings suggest that low-level light, when applied appropriately, ...Continue Reading

References

Feb 1, 1979·The British Journal of Radiology·H F Moustafa, J W Hopewell
Jan 1, 1992·Lasers in Surgery and Medicine·M RezvaniE M Whitehouse
Dec 1, 1991·The British Journal of Radiology·P S MortimerJ W Hopewell
Jan 1, 1989·Lasers in Surgery and Medicine·S YoungC Diamantopoulos
Mar 1, 1988·The British Journal of Radiology·G M Morris, J W Hopewell
Mar 1, 1986·The Keio Journal of Medicine·T FujinoT Ohshiro
Feb 1, 1987·The Journal of Dermatologic Surgery and Oncology·R P AbergelJ Uitto
Jan 1, 1987·Annals of Plastic Surgery·R F LyonsJ Uitto
Jan 1, 1985·Lasers in Surgery and Medicine·E MesterA Mester
Mar 1, 1985·Annals of Plastic Surgery·T KamiT Fujino
Jan 1, 1985·Lasers in Surgery and Medicine·J S McCaughanW Janssen
Jul 1, 1983·British Medical Bulletin·B J Whittle, S Moncada
Jan 1, 1983·Lasers in Surgery and Medicine·F H JongsmaJ P Hulsbergen Henning
Jan 1, 1983·Lasers in Surgery and Medicine·J S SurinchakM Belkin
May 1, 1982·The British Journal of Radiology·J W Hopewell, C M Young

❮ Previous
Next ❯

Citations

Aug 19, 2004·Photomedicine and Laser Surgery·Lynda D WoodruffChukuka S Enwemeka
Feb 7, 2009·Photomedicine and Laser Surgery·Kelly Steinkopf CaetanoChukuka S Enwemeka
Mar 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Judith A E M ZechaRené-Jean Bensadoun
Nov 30, 2012·IEEE Journal of Biomedical and Health Informatics·S M PereiraP M Azevedo Marques
Jan 12, 2021·Journal of Lasers in Medical Sciences·Vahid MansouriMostafa Hamdieh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the Society for Experimental Biology and Medicine
B H Porras-ReyesT A Mustoe
Lasers in Surgery and Medicine
M A Trelles, E Mayayo
Lasers in Surgery and Medicine
S YoungC Diamantopoulos
American Journal of Surgery
E MesterJ G Tota
© 2021 Meta ULC. All rights reserved