Modification of layered atelocollagen: enzymatic degradation and cytotoxicity evaluation

Biomaterials
K VizárováJ Koller

Abstract

Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-linked with HMDIC. This should offer the possibility of programmed enzymatic degradation. These materials may be toxicologically acceptable as proven by the short-term test used for cytotoxicity evaluation.

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Citations

Mar 1, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Sona JantovaPatrik Matejov
Apr 27, 2013·Carbohydrate Polymers·Yuanting XuYaping Wang
Oct 22, 2015·BioResearch Open Access·Valerio RussoLauren E Flynn

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