PMID: 9541460Apr 16, 1998Paper

Modification of macrophage response to lipopolysaccharide by fetuin

Immunology Letters
K M DziegielewskaN R Saunders

Abstract

The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding to fetal levels of this protein in plasma, the production and secretion of interleukin 1beta (IL-1beta) and nitric oxide (NO) is almost abolished, tumour necrosis factor-alpha (TNF-alpha) reduced, while that of IL-6 is not affected. On the other hand, concentrations of fetuin corresponding to adult plasma levels (i.e. 40-60 mg/100 ml) were without much effect on macrophage synthesis and secretion of these cytokines.

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Citations

Oct 12, 2000·Journal of Cellular Physiology·T TajirianC J Swallow
Feb 28, 2003·Biology of Reproduction·Peta L GrigsbyGraham Jenkin
Aug 15, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Gerald ReinerRalf Herwig
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Nov 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Satinath MukhopadhyayDeep Dutta
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Feb 27, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Violaine K HarrisSaud A Sadiq
Dec 25, 2017·Journal of Dairy Science·Clarissa Strieder-BarbozaG Andres Contreras
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Aug 12, 2005·Journal of the American Society of Nephrology : JASN·Joanne L ReynoldsCatherine M Shanahan
Nov 27, 2019·Journal of Clinical Medicine·Lynda Bourebaba, Krzysztof Marycz
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Jan 15, 2021·Journal of Affective Disorders·Elettra MancusoFrancesco Andreozzi
Sep 3, 2010·Biochemistry·Jana HedrichChristoph Becker-Pauly

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