Abstract
To determine the effects of the nitric oxide synthase inhibitor, nitro-L-arginine on energy metabolism in transplantable and spontaneous murine tumors. The responses of the transplantable murine tumor SCCVII/Ha and a range of spontaneously arising murine mammary adenocarcinomas to 10 mg/kg IV nitro-L-arginine were examined using in vivo 31P magnetic resonance spectroscopy (MRS). The influence of Hypnorm/Hypnovel anesthesia on the response to nitro-L-arginine was also determined in the SCCVII/Ha tumors. Data were expressed as changes in the inorganic phosphate peak area relative to the sum of all peak areas from the 31P MR spectrum, or Pi/total. Nitro-L-arginine at 10 mg/kg IV increased Pi/total 2-3-fold in the SCCVII/Ha tumors for at least 2 h after administration, in both anesthetized and nonanesthetized mice, consistent with increased tumor hypoxia. Similar increases in Pi/total were observed after 10 mg/kg IV nitro-L-arginine in 13 spontaneous murine tumors from three different mouse strains, where anesthetic was used. The results indicate that tumor metabolism may be modified by an inhibitor of nitric oxide synthesis, that this modification occurs in both transplantable and spontaneous murine tumors and is not affected by a...Continue Reading
Citations
Aug 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G E AdamsM C Joiner
Sep 7, 2000·International Journal of Radiation Oncology, Biology, Physics·B F JordanB Gallez
Dec 9, 1998·International Journal of Radiation Oncology, Biology, Physics·G M TozerD J Chaplin
Jan 9, 1999·Bioorganic & Medicinal Chemistry·S UlhaqM D Threadgill
Jan 1, 1996·Nutrition and Cancer·R M MillisM E Reynolds
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G U Dachs, G M Tozer
Feb 12, 1998·Cancer Letters·J E Downing
Mar 29, 2007·Radiation Research·Peter WardmanPeter J Johnston
Jun 8, 2011·PloS One·Robert J G Cardnell, Ross B Mikkelsen
Sep 20, 2011·Marine Pollution Bulletin·Abigail M SmithCeridwen I Fraser
Jul 5, 2005·Expert Opinion on Investigational Drugs·R M Phillips
Feb 22, 2002·British Journal of Cancer·E C ChinjeI J Stratford
Feb 21, 2002·The Journal of School Nursing : the Official Publication of the National Association of School Nurses·Joyce PulciniDeirdre Mole
Mar 1, 1995·Cancer Treatment Reviews·S M SagarA C Whitton
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·G M Tozer, S A Everett
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·G M Tozer, S A Everett
Jun 20, 1998·Seminars in Radiation Oncology·D J ChaplinG M Tozer