PMID: 4694405Mar 10, 1973Paper

Modification of plasma corticosteroid concentrations during and after surgery by epidural blockade

British Medical Journal
N H GordonI W Percy Robb

Abstract

The adrenocortical response to major surgery was assessed by the measurement of plasma corticosteroid concentrations in patients receiving either a general anaesthetic alone or in combination with an epidural block. The expected increase in plasma corticosteroid concentration seen in the general anaesthesia group was significantly inhibited by epidural block. The inhibition was related to the duration of the epidural block. The lack of the normal adrenocortical response to surgery was not associated with cardiovascular collapse and indeed did not seem detrimental in any way. These findings question the need for corticosteroid "cover" for the stress of surgery in patients who have been taking corticosteroid drugs.

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Citations

Aug 1, 1994·Diseases of the Colon and Rectum·G D HarmonM J Warzynski
Sep 1, 1979·Canadian Anaesthetists' Society Journal·G M CooperJ Alaghband-Zadeh
May 1, 1979·Canadian Anaesthetists' Society Journal·H IshiharaT Oyama
Jan 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I MuratC Saint-Maurice
Jan 1, 1985·Psychoneuroendocrinology·T K McIntoshR H Egdahl
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·A EngquistH Kehlet
Apr 29, 1978·British Medical Journal·M R BrandtH Kehlet
Nov 14, 1997·Anesthesia and Analgesia·R VilàN Potau
Nov 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·P C BuchanM C Browning
May 1, 1987·Baillière's Clinical Endocrinology and Metabolism·R C Gaillard, S Al-Damluji
Mar 1, 1985·The Journal of Surgical Research·T K McIntoshR H Egdahl
Nov 1, 1986·Acta Anaesthesiologica Scandinavica·B W JakobsenB B Egeberg
Dec 1, 1979·The British Journal of Surgery·N M Gow, J P Cochrane
Feb 1, 1983·The British Journal of Surgery·H TsujiC Shirasaka
Mar 1, 1976·Clinical Endocrinology·M BrandtA S McNeilly
Sep 1, 1986·British Journal of Obstetrics and Gynaecology·P G LoughranJ W Dundee
Aug 1, 1991·Anaesthesia and Intensive Care·J R Rigg
Mar 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·H KehletJ Rem
Mar 27, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Sema TuncerSeref Otelcioglu
Nov 21, 2007·Journal of Perioperative Practice·Saqeb MirzaSamira Akmal
Apr 1, 1984·Anaesthesia·W F HamiltonJ Feely
Jul 1, 1981·Anaesthesia·G M CooperG M Hall
Jun 1, 1980·Zeitschrift für Ernährungswissenschaft·M GeorgieffH Lutz

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