Modification of polyethylene terephthalate (Dacron) via denier reduction: effects on material tensile strength, weight, and protein binding capabilities

Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials
Matthew D PhaneufF W LoGerfo

Abstract

Thrombosis remains a significant and potentially catastrophic complication of polyethylene terephthalate (Dacron) prosthetic vascular graft implantation. Numerous attempts have been made to create a novel surface that reduces the adverse effects of blood interaction with the material. The purpose of this study was to create reactive groups on Dacron without significantly altering the chemical and physical properties of the biomaterial. These groups would then serve as "anchor sites" for covalent attachment of the blood protein albumin to the surface, thus creating a more biocompatible surface. Denier reduction, an established textile chemistry procedure that creates carboxyl groups on the fiber surface via hydrolysis of the material, was performed at 100 degrees C using sodium hydroxide concentrations of 0.5, 1.0, 2.5, and 5.0% (treated materials referred to as 0.5% hydrolyzed etc.). Tensile strength determination of hydrolyzed materials revealed no statistically significant difference in material strength between control, 0.5, and 1.0% hydrolyzed materials; the 2.5 and 5.0% hydrolyzed materials had significant strength loss as compared to the controls. Significant fiber weight loss occurred in the 1.0, 2.5, and 5.0% hydrolyzed...Continue Reading

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Citations

Mar 18, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M C WyersW C Quist
Jan 23, 1999·Archives of Physiology and Biochemistry·G W BosJ Feijen
Aug 21, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Puja AggarwalMatthew D Phaneuf
May 4, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R GhiselliV Saba
Jan 24, 2009·Journal of Biomedical Materials Research. Part a·Weilin XuBugao Xu
Jul 20, 2005·Journal of Biomedical Materials Research. Part a·Matthew D PhaneufFrank W LoGerfo
Dec 10, 2008·The Journal of the Acoustical Society of America·Hongyu MiaoDiane Dalecki

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