PMID: 640751Jan 1, 1978Paper

Modification of prostaglandin and thromboxane release by immunological sensitisation and successive immunological challenges from guinea-pig lumg

International Archives of Allergy and Applied Immunology
J R BootD J Osborne

Abstract

The release of prostaglandins (PGs) and thromboxanes (Txs) from perfused guinea pig lungs was investigated during different immunological states. The major product released from normal lungs perfused with exogenous arachidonic acid was 6-oxo-PGF1a. The procedure of sensitisation to specific antigen resulted in an increase in the release of 15-oxo-13,14-dihydro-TxB2 and a decrease in the release of 6-oxo-PGF1a- and 6,15-dioxo-13,14-dihydro-PGF1a from lungs perfused with arachidonic acid. The relative amount of 15-oxo-13,14-dihydro-TxB2 released progressively increased with the number of immunological challenges with both exogenous and endogenously derived substrate, arachidonic acid. This change in response to successive immunological challenges may represent a protective mechanism to prevent parent Txs and PGs entering the systemic circulation.

Citations

Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·W Dorsch, L Frey
Mar 1, 1979·European Journal of Pharmacology·K M MullaneJ R Vane
Aug 22, 1980·European Journal of Pharmacology·M A WassermanG L Degraaf
Nov 1, 1977·Prostaglandins·K I Williams, I Downing
Jan 1, 1982·Prostaglandins·R KorbutT Eling
Nov 1, 1985·Acta Radiologica: Diagnosis·H Paajanen, P Uotila
May 1, 1982·Acta Pharmacologica Et Toxicologica·P Uotila
Aug 1, 1982·The Journal of Pharmacy and Pharmacology·C Robinson, J R Hoult
Nov 1, 1979·Annals of Clinical Biochemistry·E Granström

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.