PMID: 7543593Sep 1, 1995Paper

Modification of retroviral RNA by double-stranded RNA adenosine deaminase

Journal of Virology
A M Hajjar, M L Linial

Abstract

In this report, we describe a recombinant provirus generated during in vitro passage that contains a short region of adenosine-to-guanosine hypermutation. The hypermutated region is restricted to complementary sequences present in the recombinant provirus. We propose that a duplex was formed in the recombinant RNA prior to reverse transcription. This duplex was a substrate for double-stranded RNA adenosine deaminase, an activity found in all cells examined that deaminates A in double-stranded RNA, converting it to inosine, which is further converted to a guanosine by reverse transcription. It appears that cis viral sequences facilitated the A-->G transitions.

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Citations

Jun 5, 2002·Annual Review of Biochemistry·Brenda L Bass
Jul 28, 2010·Journal of Virology·Michael E AbramStephen H Hughes
Apr 13, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J A Majde
Nov 28, 2009·BMC Genetics·Jennifer A CarpenterFrancis M Jiggins
Jan 28, 2014·PLoS Pathogens·Marine Combe, Rafael Sanjuán
Jan 1, 1997·Annual Review of Phytopathology·M J Roossinck
Dec 30, 2014·Retrovirology·Kathrin GibbertUlf Dittmer
Sep 20, 2000·The Journal of General Virology·S GoodbournR E Randall
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Kumar, G G Carmichael
Jan 1, 1996·Trends in Microbiology·B D Preston, J P Dougherty
Nov 30, 2002·Biochimie·Myriam Schaub, Walter Keller
Dec 1, 1996·Molecular and Cellular Biology·J Cao, A P Geballe
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M Kumar, G G Carmichael
Jan 15, 2005·Virus Research·Robert A SmithBradley D Preston
Jul 20, 2021·Frontiers in Microbiology·Marianoel Pereira-GómezGonzalo Moratorio
Apr 22, 2021·Annual Review of Virology·Christian K PfallerCharles E Samuel

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