PMID: 6105881Aug 4, 1980Paper

Modification of sodium inactivation in myelinated nerve by Anemonia toxin II and iodate. Analysis of current fluctuations and current relaxations

Biochimica Et Biophysica Acta
B NeumckeR Stämpfli

Abstract

(1) Na+ currents and Na+ current fluctuations were measured in single myelinated nerve fibres of Rana esculenta under voltage-clamp conditions. The process of Na+ inactivation was modified by external treatment with 7 microM Anemonia Toxin II or by internal application of 20 or 40 mM IO3(-). (2) At depolarization of 24 and 32 mV the spectral density of Na+ current fluctuations could be described as the sum of two contributions, Sh(f) and Sm(f), representing the spectrum from fluctuations of the inactivation (h) and activation (m) gates, respectively. At higher depolarizations of 40 and 48 mV the low frequency (h) fluctuations could be better fitted by the sum, Sh1(f)+Sh2(f), of two separate Lorentzian functions. (3) The Na+ current and the variance of Na+ current fluctuations between 150 and 450 ms after depolarization are increased by one order of magnitude after application of Anemonia Toxin II or IO3(-). (4) The kinetics of Na+ current inactivation were described as A1 x exp(-t/tau h1) + A2 x exp(-t/tau h2) + B. The constant, tau h1, of fast Na+ inactivation was the same in normal and modified nerve fibres. The slow inactivation time constant, tau h2, increased with increasing depolarizations in modified fibres but decreased...Continue Reading

References

Nov 16, 1979·Biochimica Et Biophysica Acta·B NeumckeR Stämpfli
May 15, 1974·Experientia·R Stämpfli

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Citations

Aug 1, 1980·Pflügers Archiv : European journal of physiology·B NeumckeR Stämpfli
May 1, 1985·Pflügers Archiv : European journal of physiology·J Schmidtmayer
Oct 1, 1982·Pflügers Archiv : European journal of physiology·J SchmidtmayerW Ulbricht
Sep 1, 1984·Pflügers Archiv : European journal of physiology·H MevesD D Watt
May 1, 1985·Pflügers Archiv : European journal of physiology·K Hartung, W Rathmayer
Dec 1, 1983·Pflügers Archiv : European journal of physiology·K NagyD Hof
Aug 1, 1983·Pflügers Archiv : European journal of physiology·J SchmidtmayerW Ulbricht
Jun 1, 1981·Pflügers Archiv : European journal of physiology·B NeumckeR Stämpfli
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·M RackH H Grünhagen
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·C Erxleben, W Rathmayer
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·A R KhanJ Molgo
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·I TesserauxG Schumann
Jan 1, 1985·Progress in Biophysics and Molecular Biology·B I Khodorov
Mar 1, 1983·The Journal of General Physiology·A Warashina, S Fujita
Nov 1, 1985·The Journal of General Physiology·G K Wang, G Strichartz
Jul 20, 1981·Biochimica Et Biophysica Acta·G OchsJ R Schwarz
Sep 1, 1985·British Journal of Pharmacology·J B HarrisI Tesseraux
Sep 27, 2005·Physiological Reviews·Werner Ulbricht

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