Modification of specific regions of the human cytomegalovirus genome during in vitro passage.

The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses
C Hamelin, M Dion

Abstract

Different regions of the human cytomegalovirus strain AD-169 DNA molecule were tested for stability using cloned Hind III fragments. Results indicate that insertion, deletion and/or rearrangement of nucleotide sequences occur at a relatively high frequency in all parts of the human cytomegalovirus genome during in vitro passage.

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