PMID: 6412228Sep 1, 1983Paper

Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA

Proceedings of the National Academy of Sciences of the United States of America
Y IkeD B Clewell

Abstract

Recipient strains of Streptococcus faecalis excrete multiple, peptide sex pheromones that induce mating responses in donors harboring certain conjugative plasmids. Acquisition of plasmid DNA leads to a "shutting off" of pheromone excretion, and such cells become responsive to exogenous pheromone. Data are presented showing that donors excrete low levels of a modified, inactive form of the pheromone. This substance, when mixed in excess with active pheromone, inhibits pheromone activity (probably by competition for a receptor site on the donor). Modified forms of both cPD1 and cAD1 were revealed, and each appeared to have a mass about 350-400 daltons larger than the active pheromone. In both cases, pheromone activity could be regenerated by treatment with phosphodiesterase II.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G M DunnyD B Clewell
Jan 1, 1978·Annual Review of Microbiology·J Davies, D I Smith
Aug 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·B M ShapiroE R Stadtman
Nov 18, 1982·Nature·C Gawron-Burke, D B Clewell

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Citations

Apr 1, 1988·Biochimie·G F Fitzgerald, M J Gasson
Dec 31, 2003·International Journal of Food Microbiology·María Teresa GarcíaAntonio Gálvez
May 8, 2004·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·K YamamotoT Takahashi
Aug 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·María Victoria FranciaGabriel Moncalián
Apr 1, 1988·Antimicrobial Agents and Chemotherapy·B E MurrayD B Clewell
Feb 1, 1990·Antimicrobial Agents and Chemotherapy·S HandwergerA Kolokathis
Feb 7, 2003·Applied and Environmental Microbiology·Marta DiazMercedes Maqueda
Feb 22, 2003·Infection and Immunity·Claudia Gentry-WeeksDale Baker
Mar 24, 2005·Infection and Immunity·Andrew L KauScott J Hultgren
Jan 12, 2000·Journal of Bacteriology·C M GibsonM G Caparon

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