PMID: 6172540Jan 1, 1982Paper

Modification of T cell antinuclease idiotype expression by in vivo administration of anti-idiotype

The Journal of Experimental Medicine
G MillerD H Sachs

Abstract

Immunization of BALB/c mice with nuclease leads to the production of anti-nuclease antibodies bearing a set of cross-reactive idiotypes (Id) distinct from those produced by B10.D2 mice after similar immunization. In both strains, such immunization with nuclease also leads to the production of splenic T helper cells (TH), which provide nuclease-specific help in an in vitro plaque-forming cell response to nuclease-TNP. Pig anti-(BALB/c antinuclease) anti-idiotypic antibodies (pig anti-BALB/c Id) react only with TH of nuclease-primed BALB/c and not with B10.D2 animals. After administration of pig anti-BALB/c Id in complete Freund's adjuvant to BALB/c and B10.D2 mice, Id-bearing nonantigen-binding molecules were induced in both strains. Such treatment also resulted in the induction of nuclease-specific splenic TH cells in both strains. BALB/c TH cells induced by anti-Id, like the majority of nuclease-primed BALB/c TH cells, bore BALB/c Id, as shown by their functional elimination with anti-Id plus complement. B10.D2 TH cells induced by anti-Id, unlike TH cells from nuclease-primed B10.D2 mice, also bore BALB/c idiotypic determinants by the same criterion. Thus, it appears that one can manipulate the expression of Id on serum immuno...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F L OwenA Nisonoff
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jun 1, 1972·The Journal of Experimental Medicine·D A HartA Nisonoff
Jul 1, 1981·The Journal of Experimental Medicine·G G MillerD H Sachs
Jan 1, 1980·Immunological Reviews·G KelsoeK Rajewsky

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Citations

Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K NakanishiT Kishimoto
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M M Abu-HadidG L Mayers
Nov 1, 1983·European Journal of Immunology·D MaleI Roitt
Jan 1, 1983·Annals of the New York Academy of Sciences·J PèneM Stanislawski

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