Modification of the descending thoracic aortic anastomotic site using biodegradable felt: study in a canine model with or without basic fibroblast growth factor

Journal of Vascular Surgery
Hidenori FujiwaraKoichi Tabayashi

Abstract

We investigated the outcomes of reinforcing anastomotic sites using (1) nonbiodegradable polytetrafluoroethylene (PTFE) felt, (2) biodegradable polyglycolic acid (PGA) felt, and (3) PGA felt with basic fibroblast growth factor (bFGF) in a canine descending thoracic aortic replacement model. Thirty-seven beagles underwent descending thoracic aorta replacement using a prosthetic graft with one of the above-mentioned reinforcements or no reinforcement for controls. Histologic evaluations were carried out 1 month and 3 months after surgery. The biomechanical strength of the anastomosis was assessed along the longitudinal axis of the aortic segments using a tensile tester. Local compliance at the anastomotic site was also evaluated in the circumferential direction. The media was significantly thinner in the PTFE group than in the control group (65.8% +/- 5.1% vs 95.0% +/- 9.3% of normal thickness; P < .05). Relative to the control group, the adventitial layer was significantly thinner in the PTFE group (42.3% +/- 8.2% of control; P < .05) but significantly thicker in the PGA and the PGA + bFGF groups (117.2% +/- 11.3% and 134.1% +/- 14.2% of control, respectively; P < .05). There were more vessels in the adventitial layer in the PGA...Continue Reading

References

Jun 6, 2000·Advanced Drug Delivery Reviews·Y Ikada, Y Tabata
Sep 2, 2000·The Annals of Thoracic Surgery·T KatsumataS Westaby
Nov 22, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M RicciT A Salerno
Aug 26, 2004·Congenital Anomalies·Yasuhiko Tabata
Mar 1, 2005·The Annals of Thoracic Surgery·Justus T StrauchRandall B Griepp
Sep 23, 2008·The Annals of Thoracic Surgery·Shinichi SatoKoichi Tabayashi

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Citations

Feb 8, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katsuhiro HosoyamaYoshikatsu Saiki
Sep 22, 2017·Bioengineering & Translational Medicine·Karyn G RobinsonRobert E Akins

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