Modification of the EORTC QLQ-C30 (version 2.0) based on content validity and reliability testing in large samples of patients with cancer. The Study Group on Quality of Life of the EORTC and the Symptom Control and Quality of Life Committees of the NCI of Canada Clinical Trials Group

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
David OsobaA te Velde

Abstract

A revision of the Quality of Life Questionnaire (QLQ-C30) of the European Organization for Research and Treatment of Cancer (EORTC) was undertaken to improve low internal consistency estimates (Cronbach's alpha) and content validity for the role functioning scale and a conceptual difficulty (undue emphasis on physical functioning) in the global quality of life (QOL) scale. The role functioning items were reworded and a four-category response format was substituted for the previous dichotomous format. A new item asking about 'overall health' was substituted for the 'overall physical condition' item in the global QOL domain. The original and new versions were tested at three time points in a total of 1,181 patients with cancer in Canada (n = 696) and the Netherlands (n = 485). In both samples there was a marked improvement in internal consistency for the role functioning scale (Cronbach's alpha s ranging from 0.78-0.88) in the new version. In the global QOL scale, the substitution of the new item for the previous one did not alter internal consistency (Cronbach's alpha's ranging from 0.81-0.92). The revised versions of the role functioning and global QOL domains have been incorporated into the QLQ-C30 (version 2.0).

Citations

Mar 11, 2003·Cancer·Bernhard HolznerBarbara Sperner-Unterweger
Jul 31, 2008·Journal of the National Cancer Institute·Christine HerbstUNKNOWN Cochrane Haematological Malignancies Group
Apr 20, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Nina RottmannChristoffer Johansen
Oct 16, 2013·Cancer·Chantal QuintenUNKNOWN Patient Reported Outcomes and Behavioral Evidence (PROBE) and the European Organization for Research and Treatment of Cancer
Sep 24, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Brett Doble, Paula Lorgelly
Sep 28, 2017·Pigment Cell & Melanoma Research·Karen A MalkhasyanMohammed Milhem
Aug 2, 2003·Annals of Surgery·Jutta EngelDieter Hölzel
Aug 8, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·K BudischewskiSt Mose
May 5, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Mercedes Nicklasson, Bengt Bergman
Jun 1, 2008·Expert Review of Pharmacoeconomics & Outcomes Research·Michael BrundageJoseph Pater
Sep 29, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Susan HorsmanSunita Ghosh
Sep 10, 2013·Journal of Psychosocial Oncology·Sanne W van den BergJudith B Prins
Jan 17, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Floortje K Ploos van AmstelPetronella B Ottevanger
Jul 27, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Nancy E AvisCharles S Carver
Nov 17, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·N W ScottUNKNOWN EORTC and the Quality of Life Cross-Cultural Meta-Analysis Group
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander SunHak Choy
Dec 22, 2011·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Chad M GundyNeil K Aaronson
Mar 5, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Floortje K Ploos van AmstelPetronella B Ottevanger

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