Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Enyu ImaiSeiichi Matsuo

Abstract

Glomerular filtration rate (GFR)-estimating equations based on serum creatinine level may not be accurate across racial groups because of differences among races in creatinine generation. The Modification of Diet in Renal Disease (MDRD) Study equation was developed in whites and African Americans, but performance was not evaluated in Japanese. Diagnostic test accuracy. Cross-sectional retrospective study of 3 patient groups. Equation development in 2 groups (n = 247 in 2002 to 2004; n = 214 in 2003 to 2004 with measured GFR <90 mL/min/1.73 m(2)); external validation in a separate group (n = 153 from 1988 to 1994). Hospitalized Japanese patients with chronic kidney disease in 3 medical centers. Measured GFR (mGFR) computed from renal clearance of inulin. Estimated GFR (eGFR) using the isotope dilution mass spectrometry (IDMS)-traceable 4-variable MDRD Study equation, a modified IDMS MDRD Study equation with a Japanese Society of Nephrology-Chronic Kidney Disease Initiatives (JSN-CKDI) coefficient derived in the development data set, and a new equation derived by refitting coefficients in the MDRD Study equation in the development data set. Current creatinine assays were calibrated to standardized creatinine. Performance of equat...Continue Reading

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