Modification of the mutagenicity of aflatoxin B1 and N-methyl-N'-nitro-N-nitrosoguanidine by certain phenolic compounds

Cancer Letters
A R FrancisR K Bhattacharya

Abstract

Five natural and two synthetic phenolic compounds were tested for their ability to suppress mutagenicity of aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium tester strain TA100. Caffeic acid and eugenol were observed to inhibit mutagenicity of both the carcinogens, while chlorogenic acid was effective in the case of AFB1 alone and ellagic acid and butylated hydroxytoluene were found to be antimutagenic only for MNNG. These differential activities of the phenolic compounds appeared to be due to their different modes of action towards direct and indirect acting carcinogens.

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Citations

Jan 5, 1996·Chemico-biological Interactions·C J RompelbergP J van Bladeren
Sep 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C J RompelbergP J van Bladeren
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Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SinghR Bamezai
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May 1, 1994·Journal of Dental Research·J H JengM Y Kuo
Dec 23, 2004·Journal of Radiation Research·Ashu Bhan TikuRaosaheb K Kale

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