PMID: 3754643Mar 1, 1986Paper

Modification of the radiosensitizing effect of metronidazole by 5-fluorouracil and caffeine

Radiobiologiia
G O Esel'baeva, S A Ermekova

Abstract

A study was made of the combined effect of 5-fluorouracil, metronidazole, caffeine and radiation on radiosensitivity of Pliss lymphosarcoma and protein synthesis rate during the first few hours following irradiation. A complete regression of the tumor was noted in 100% of animals after a 3-fold exposure. Effective postirradiation inhibition of protein synthesis was achieved by injection of metronidazole and caffeine together with 5-fluorouracil.

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