PMID: 6983746Sep 1, 1982Paper

Modification of thymocytes subsets during pregnancy analysed by flow microfluorometry: role of the alloantigenic status of the conceptus

Thymus
G ChaouatR Asofsky

Abstract

Modifications of thymus subsets during pregnancy were monitored using flow microfluorometry and fluorescein-labelled lectins or antibodies. Essentially, it was found that the percentage of peanut lectin-negative (PNA-) cells increased significantly during pregnancy. More interestingly, in the strains tested, the percentage of PNA- cells was more increased in allogeneic than syngeneic pregnancy. This PNA- increase could be mimicked by extracts from syngeneic placenta, but the largest increase in PNA- cells was always observed by injection of allogeneic placental extract, or syngeneic placental extract plus allogeneic cells. These findings suggest that the alloantigenic status of the conceptus does play a role in induction/maintenance of thymus involution, suggesting that it is not a mere hormonal phenomenon and that it could play a role in the events leading to the acceptance of the allogeneic conceptus by the maternal immune system.

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