Modification of tissue factor by peroxynitrite influences its procoagulant activity

FEBS Letters
J M AdamK R Bruckdorfer

Abstract

Peroxynitrite, a reactive oxidising species resulting from a reaction between nitric oxide and the superoxide anion, modifies proteins by nitration of certain amino acids such as tyrosine. Tissue factor (TF), a transmembrane protein, is expressed on cells under inflammatory conditions and initiates the coagulation cascade. The extracellular domain of TF is rich in tyrosine. Exposure of recombinant TF and cellular TF to peroxynitrite was associated with a reduction in procoagulant activity. This was accompanied by an elevated level of nitrotyrosine residues. Peroxynitrite may have a protective role by attenuation of the thrombotic properties of TF.

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Citations

Jul 31, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·K R Bruckdorfer
Oct 19, 2001·British Journal of Pharmacology·P MinuzA Lechi
Dec 14, 2011·Free Radical Biology & Medicine·Peter R Kvietys, D Neil Granger
Jul 30, 2004·Anesthesia and Analgesia·Vance G NielsenDale A Parks
Apr 24, 2004·Anesthesia and Analgesia·Vance G NielsenDale A Parks
Feb 26, 2004·Anesthesia and Analgesia·Vance G Nielsen, John P Crow

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