PMID: 8442962Jan 1, 1993Paper

Modification of tonic-clonic convulsions by atracurium in multiple-monitored electroconvulsive therapy

Journal of Clinical Anesthesia
P W LuiK K Chan

Abstract

To determine the effect of two different doses of atracurium on the modification of tonic-clonic convulsions in multiple-monitored electroconvulsive therapy (MMECT). To compare recovery time and adverse reactions of these doses. Clinical study. Anesthesiologist was blinded in the evaluation of post-electroconvulsive therapy (ECT) myalgia and other side effects. University-affiliated veterans general hospital. Two groups of twelve psychiatric inpatients who suffered from major depression or catatonic-type schizophrenia that failed to respond to tricyclic antidepressant therapy. Under single-channel, prefrontal electroencephalographic (EEG) monitoring, patients were given either 0.3 mg/kg or 0.5 mg/kg of atracurium intravenously (IV) after anesthetic induction with methohexital 1 mg/kg i.v. Evoked electromyographic responses of the adductor pollicis muscle was obtained by train-of-four stimulation of the ulnar nerve at the wrist every 20 seconds. The first twitch depression (T1) of neuromuscular blockade was maintained within 11% to 25% (atracurium 0.3 mg/kg) or 0% to 10% (atracurium 0.5 mg/kg) of control during the entire session of MMECT. Patients pretreated with atracurium 0.5 mg/kg had significantly fewer ECT-induced moderate...Continue Reading

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Citations

Feb 13, 2007·Der Anaesthesist·U Grundmann, M Oest
Sep 7, 2005·CNS Drugs·Klaus J WagnerEberhard F Kochs
Nov 19, 2011·Acta Anaesthesiologica Scandinavica·H MirzakhaniA Nozari
Apr 23, 2005·The Cochrane Database of Systematic Reviews·P Tharyan, C E Adams
Mar 25, 2020·The Journal of ECT·Laura Aleida Christina Mulder, Koen Pieter Grootens
Apr 26, 2002·Anesthesia and Analgesia·Zhengnian Ding, Paul F White

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