Modification of Tp-e and QTc intervals during caesarean section under spinal anaesthesia

Anaesthesia
A GuillonM Laffon

Abstract

There are no guidelines for the anaesthetic management of caesarean section in women with long QT syndrome; the description of myocardial ventricular repolarisation in healthy women during caesarean delivery could be a first step. The aim of this study was to describe modification of the QT interval, corrected for heart rate, and the interval between the peak and the end of the T-wave (Tpeak-Tend interval) during caesarean section under spinal anaesthesia. We studied 40 patients scheduled for caesarean section under spinal anaesthesia. Patients were randomly assigned to receive either ephedrine or phenylephrine to prevent hypotension. We injected 5 IU oxytocin after delivery. Corrected QT and Tpeak-Tend intervals were unchanged from pre-operative values after induction of spinal anaesthesia, but increased significantly after oxytocin injection. The choice of vasopressor did not affect the Tpeak-Tend interval. The risk-benefit balance of oxytocin bolus during caesarean delivery should be discussed with women with a history of long QT syndrome.

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Citations

May 18, 2012·British Journal of Anaesthesia·B CharbitJ Weissenburger
Dec 7, 2013·British Journal of Anaesthesia·C StaikouE Stavroulakis
Aug 21, 2013·International Journal of Obstetric Anesthesia·M BruyereB Charbit
Feb 19, 2015·Pharmacology Research & Perspectives·Yusheng QuHugo M Vargas
Aug 20, 2016·Nigerian Journal of Clinical Practice·G BatmazB Dane
Apr 3, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ilona BodiKatja E Odening
Oct 5, 2017·The Cochrane Database of Systematic Reviews·Cheryl ChooiAllan M Cyna
Jul 4, 2020·The Cochrane Database of Systematic Reviews·Cheryl ChooiAllan M Cyna
Jan 27, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Naoko NiimiKatherine Zaleski

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