PMID: 9541441Apr 16, 1998Paper

Modification of trabeculectomy with single-dose intraoperative 5-Fluorouracil application

Acta Ophthalmologica Scandinavica
N AnandM J Menage

Abstract

To assess the outcome of trabeculectomy supplemented with intraoperative 5-Fluorouracil (5 FU) application in glaucoma patients. A prospective non-randomized case series of 76 eyes of 76 consecutive patients who underwent trabeculectomy with intraoperative sponge 5 FU (25 mg/ml). Minimum follow-up was 6 months. There were 31 eyes in the low-risk group and 45 eyes in the high-risk group. The reduction in intraocular pressure (IOP) and any treatment complications were noted. The mean preoperative IOP was 28+/-7.72 mm Hg. The mean final postoperative IOP was 16.8+/-6.1 mm Hg. The average number of glaucoma medications required dropped from 1.8+/-0.8 preoperatively to 0.4+/-0.8 after the operation (p<0.001). Cumulative success rates (IOP less than 21 mm Hg) for all eyes were 93% and 81% at 6 and 12 months, respectively. There was no difference in outcome between the low- and high-risk groups if criteria for success were an IOP of less than 21 mm Hg or an IOP of less than 21 mm Hg and an IOP reduction of 30%. However, if success is defined as an IOP of 15 mm Hg or less and a 30% fall in IOP, then the low-risk group had significantly longer survival times than the high-risk group (p=0.033, log-rank test). Transient punctate keratitis...Continue Reading

Citations

Jan 13, 2009·International Ophthalmology·Andrea ZarkovicJustin S Mora
May 15, 2003·Survey of Ophthalmology·Paul J Lama, Robert D Fechtner
Oct 23, 2002·Acta Ophthalmologica Scandinavica. Supplement·F M GrignoloA M Fea
Oct 28, 1999·Current Opinion in Ophthalmology·E K Donohue, G A Cioffi
Oct 28, 1999·Current Opinion in Ophthalmology·N S BorisuthT Krupin
Apr 26, 2002·The British Journal of Ophthalmology·M AkimotoN Yoshimura
Feb 8, 2007·Drugs·Lekha M AbrahamIgal Leibovitch
Feb 12, 2013·American Journal of Ophthalmology·Judith EhaNorbert Pfeiffer

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