PMID: 11330827May 2, 2001Paper

Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumour growth inhibition by gamma-linolenic acid

Molecular and Cellular Biochemistry
A Colquhoun, R I Schumacher

Abstract

Walker 256 tumour-bearing rats were fed pelleted chow containing low-gamma-linolenic acid (GLA) (2.98%) or high-GLA (5.55%) during the twelve-day period after subcutaneous implantation of the tumour. The presence of n-6, polyunsaturated GLA in the diet caused a concentration-dependent decrease in tumour growth, reaching an almost 50% reduction in final tumour weight in the high-GLA group. The eicosatrienoic acid content of the whole tumour homogenate and of the Percoll-purified mitochondrial fraction was increased by the GLA-rich diets. Changes in the fatty acid composition of the cytoplasmic acyl CoA pool were also found, with increases in GLA content in both the low- and high-GLA groups. Additionally, increases in eicosatrienoic acid and arachidonic acid were found in the high-GLA group. Both the cytoplasmic acyl CoA content and the mitochondrial acyl CoA synthetase activity were increased by GLA in the diet and lipid peroxidation was also increased as determined by an increase in TBARS content. Changes in mitochondrial fatty acid composition were accompanied by a decrease in the mitochondrial membrane potential in the high-GLA group. Tumours from the control and GLA groups were examined by transmission electron microscopy. T...Continue Reading

Citations

Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·Simona SeriniGabriella Calviello
Apr 30, 2010·Molecular Neurobiology·Alison Colquhoun
May 4, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Undurti N Das
Sep 29, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S AbelW C A Gelderblom

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